Phenion® Full-Thickness Skin Model
Henkel and Dermatest intensify their business relations Dermatest and Henkel have confirmed their intention to closer cooperate in the field of in in vitro dermatological testing, based on the innovative Phenion® Full-Thickness (FT) Skin Model. The agreement between both companies will strengthen Henkel’s position as Dermatest’s preferred supplier of full-thickness skin equivalents, whereas Dermatest will benefit from the long-standing experiences of the Henkel scientists in dermatology and in vitro methods.
Henkel operates globally with a well-balanced and diversified portfolio. The company holds leading positions with its three business units, Beauty Care, Laundry & Home Care, and Adhesive Technologies in both industrial and consumer businesses thanks to strong brands, innovations and technologies.
Phenion, a Henkel brand, is a synonym for more than 15 years of state-of-the-art expertise in the development of alternatives to animal testing, in vitro research and tissue engineering. With its innovative 3D tissue models of the human skin Phenion is strongly committed to the 3R principles – the reduction, refinement and replacement of animal tests (Russell & Burch, 1959), with a special focus on the third R, the complete replacement of animal experiments by in vitro methods.
For many in vitro applications Dermatest trusts in the Phenion® Full-Thickness (FT) Skin Model. This state-of-the art 3D tissue equivalent is used to study e.g. the integrity of the skin barrier, dermal differentiation processes, tissue viability, cell proliferation rate and many more parameters after exposure to a cosmetic formulation.
“We appreciate the insert-free tissue culture which offers us maximum freedom for substance application and analytical procedures.”, says Dr. Lars Rüther, Study Director at Dermatest. “The models can be easily handled in our labs due to their robustness and, what is most important, display excellent morphological and physiological properties. That’s why the Phenion® Full-Thickness Skin Model is an essential tool in Dermatest’s in vitro test portfolio.”
The Phenion® Full-Thickness Skin Model consists of both a fully differentiated epidermis and a dermis which is composed of human fibroblasts embedded in a mechanically robust collagen sponge. Its in vivo-like histological and physiological features, paired with its good handling properties, makes the Phenion® Full-Thickness Skin Model the preferred 3D FT skin equivalent at Dermatest.